Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
Identifieur interne : 000E21 ( Main/Exploration ); précédent : 000E20; suivant : 000E22Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
Auteurs : Fiona J. Mccallum [Australie] ; Kristina E M. Persson [Suède] ; Freya J I. Fowkes [Australie] ; Linda Reiling [Australie] ; Cleopatra K. Mugyenyi [Australie] ; Jack S. Richards [Australie] ; Julie A. Simpson [Australie] ; Thomas N. Williams [Kenya] ; Paul R. Gilson [Australie] ; Anthony N. Hodder [Australie] ; Paul R. Sanders [Australie] ; Robin F. Anders [Australie] ; David L. Narum [États-Unis] ; Chetan Chitnis ; Brendan S. Crabb [Australie] ; Kevin Marsh [Kenya] ; James G. Beeson [Australie]Source :
- Journal of leukocyte biology [ 1938-3673 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiprotozoaires (immunologie), Antigènes de protozoaire (immunologie), Femelle, Humains, Immunité, Immunoglobuline G (immunologie), Jeune adulte, Mâle, Mérozoïtes (immunologie), Paludisme (immunologie), Paludisme (parasitologie), Parasitémie (immunologie), Parasitémie (parasitologie), Production d'anticorps (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
- MESH :
- immunologie : Anticorps antiprotozoaires, Antigènes de protozoaire, Immunoglobuline G, Mérozoïtes, Paludisme, Parasitémie, Production d'anticorps.
- parasitologie : Paludisme, Parasitémie.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Immunité, Jeune adulte, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Protozoan (immunology), Antibody Formation (immunology), Antigens, Protozoan (immunology), Cohort Studies, Female, Humans, Immunity, Immunoglobulin G (immunology), Malaria (immunology), Malaria (parasitology), Male, Merozoites (immunology), Middle Aged, Parasitemia (immunology), Parasitemia (parasitology), Young Adult.
- MESH :
- chemical , immunology : Antibodies, Protozoan, Antigens, Protozoan, Immunoglobulin G.
- immunology : Antibody Formation, Malaria, Merozoites, Parasitemia.
- parasitology : Malaria, Parasitemia.
- Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Immunity, Male, Middle Aged, Young Adult.
Abstract
Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or prevent blood-stage replication and the development of disease. Merozoites present a complex array of antigens to the immune system, and currently, there is only a partial understanding of the targets of protective antibodies and how responses to different antigens are acquired and boosted. We hypothesized that there would be differences in the rate of acquisition of antibodies to different antigens and how well they are boosted by infection, which impacts the acquisition of immunity. We examined responses to a range of merozoite antigens in 2 different cohorts of children and adults with different age structures and levels of malaria exposure. Overall, antibodies were associated with age, exposure, and active infection, and the repertoire of responses increased with age and active infection. However, rates of antibody acquisition varied between antigens and different regions within an antigen following exposure to malaria, supporting our hypothesis. Antigen-specific responses could be broadly classified into early response types in which antibodies were acquired early in childhood exposure and late response types that appear to require substantially more exposure for the development of substantial levels. We identified antigen-specific responses that were effectively boosted after recent infection, whereas other responses were not. These findings advance our understanding of the acquisition of human immunity to malaria and are relevant to the development of malaria vaccines targeting merozoite antigens and the selection of antigens for use in malaria surveillance.
DOI: 10.1189/jlb.5MA0716-294R
PubMed: 27837017
Affiliations:
- Australie, Kenya, Suède, États-Unis
- Maryland, Svealand, Victoria (État)
- Melbourne, Stockholm
- Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000E88
- to stream PubMed, to step Curation: 000E85
- to stream PubMed, to step Checkpoint: 000E85
- to stream Ncbi, to step Merge: 003E55
- to stream Ncbi, to step Curation: 003E55
- to stream Ncbi, to step Checkpoint: 003E55
- to stream Main, to step Merge: 000E16
- to stream Main, to step Curation: 000E21
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.</title><author><name sortKey="Mccallum, Fiona J" sort="Mccallum, Fiona J" uniqKey="Mccallum F" first="Fiona J" last="Mccallum">Fiona J. Mccallum</name><affiliation wicri:level="3"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Persson, Kristina E M" sort="Persson, Kristina E M" uniqKey="Persson K" first="Kristina E M" last="Persson">Kristina E M. Persson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Reiling, Linda" sort="Reiling, Linda" uniqKey="Reiling L" first="Linda" last="Reiling">Linda Reiling</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mugyenyi, Cleopatra K" sort="Mugyenyi, Cleopatra K" uniqKey="Mugyenyi C" first="Cleopatra K" last="Mugyenyi">Cleopatra K. Mugyenyi</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Richards, Jack S" sort="Richards, Jack S" uniqKey="Richards J" first="Jack S" last="Richards">Jack S. Richards</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Williams, Thomas N" sort="Williams, Thomas N" uniqKey="Williams T" first="Thomas N" last="Williams">Thomas N. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea><wicri:noRegion>Kilifi</wicri:noRegion></affiliation></author><author><name sortKey="Gilson, Paul R" sort="Gilson, Paul R" uniqKey="Gilson P" first="Paul R" last="Gilson">Paul R. Gilson</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hodder, Anthony N" sort="Hodder, Anthony N" uniqKey="Hodder A" first="Anthony N" last="Hodder">Anthony N. Hodder</name><affiliation wicri:level="3"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sanders, Paul R" sort="Sanders, Paul R" uniqKey="Sanders P" first="Paul R" last="Sanders">Paul R. Sanders</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Anders, Robin F" sort="Anders, Robin F" uniqKey="Anders R" first="Robin F" last="Anders">Robin F. Anders</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Narum, David L" sort="Narum, David L" uniqKey="Narum D" first="David L" last="Narum">David L. Narum</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation><nlm:affiliation>Institute Pasteur, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Crabb, Brendan S" sort="Crabb, Brendan S" uniqKey="Crabb B" first="Brendan S" last="Crabb">Brendan S. Crabb</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Marsh, Kevin" sort="Marsh, Kevin" uniqKey="Marsh K" first="Kevin" last="Marsh">Kevin Marsh</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea><wicri:noRegion>Kilifi</wicri:noRegion></affiliation></author><author><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia; beeson@burnet.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27837017</idno><idno type="pmid">27837017</idno><idno type="doi">10.1189/jlb.5MA0716-294R</idno><idno type="wicri:Area/PubMed/Corpus">000E88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E88</idno><idno type="wicri:Area/PubMed/Curation">000E85</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E85</idno><idno type="wicri:Area/PubMed/Checkpoint">000E85</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E85</idno><idno type="wicri:Area/Ncbi/Merge">003E55</idno><idno type="wicri:Area/Ncbi/Curation">003E55</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E55</idno><idno type="wicri:Area/Main/Merge">000E16</idno><idno type="wicri:Area/Main/Curation">000E21</idno><idno type="wicri:Area/Main/Exploration">000E21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.</title><author><name sortKey="Mccallum, Fiona J" sort="Mccallum, Fiona J" uniqKey="Mccallum F" first="Fiona J" last="Mccallum">Fiona J. Mccallum</name><affiliation wicri:level="3"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Persson, Kristina E M" sort="Persson, Kristina E M" uniqKey="Persson K" first="Kristina E M" last="Persson">Kristina E M. Persson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Reiling, Linda" sort="Reiling, Linda" uniqKey="Reiling L" first="Linda" last="Reiling">Linda Reiling</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mugyenyi, Cleopatra K" sort="Mugyenyi, Cleopatra K" uniqKey="Mugyenyi C" first="Cleopatra K" last="Mugyenyi">Cleopatra K. Mugyenyi</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Richards, Jack S" sort="Richards, Jack S" uniqKey="Richards J" first="Jack S" last="Richards">Jack S. Richards</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Williams, Thomas N" sort="Williams, Thomas N" uniqKey="Williams T" first="Thomas N" last="Williams">Thomas N. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea><wicri:noRegion>Kilifi</wicri:noRegion></affiliation></author><author><name sortKey="Gilson, Paul R" sort="Gilson, Paul R" uniqKey="Gilson P" first="Paul R" last="Gilson">Paul R. Gilson</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hodder, Anthony N" sort="Hodder, Anthony N" uniqKey="Hodder A" first="Anthony N" last="Hodder">Anthony N. Hodder</name><affiliation wicri:level="3"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sanders, Paul R" sort="Sanders, Paul R" uniqKey="Sanders P" first="Paul R" last="Sanders">Paul R. Sanders</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Anders, Robin F" sort="Anders, Robin F" uniqKey="Anders R" first="Robin F" last="Anders">Robin F. Anders</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, Latrobe University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Narum, David L" sort="Narum, David L" uniqKey="Narum D" first="David L" last="Narum">David L. Narum</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation><nlm:affiliation>Institute Pasteur, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Crabb, Brendan S" sort="Crabb, Brendan S" uniqKey="Crabb B" first="Brendan S" last="Crabb">Brendan S. Crabb</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Marsh, Kevin" sort="Marsh, Kevin" uniqKey="Marsh K" first="Kevin" last="Marsh">Kevin Marsh</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi</wicri:regionArea><wicri:noRegion>Kilifi</wicri:noRegion></affiliation></author><author><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><affiliation wicri:level="3"><nlm:affiliation>Burnet Institute for Medical Research and Public Health, Melbourne, Australia; beeson@burnet.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Burnet Institute for Medical Research and Public Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Journal of leukocyte biology</title><idno type="eISSN">1938-3673</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Protozoan (immunology)</term><term>Antibody Formation (immunology)</term><term>Antigens, Protozoan (immunology)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Immunity</term><term>Immunoglobulin G (immunology)</term><term>Malaria (immunology)</term><term>Malaria (parasitology)</term><term>Male</term><term>Merozoites (immunology)</term><term>Middle Aged</term><term>Parasitemia (immunology)</term><term>Parasitemia (parasitology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiprotozoaires (immunologie)</term><term>Antigènes de protozoaire (immunologie)</term><term>Femelle</term><term>Humains</term><term>Immunité</term><term>Immunoglobuline G (immunologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Mérozoïtes (immunologie)</term><term>Paludisme (immunologie)</term><term>Paludisme (parasitologie)</term><term>Parasitémie (immunologie)</term><term>Parasitémie (parasitologie)</term><term>Production d'anticorps (immunologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Protozoan</term><term>Antigens, Protozoan</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiprotozoaires</term><term>Antigènes de protozoaire</term><term>Immunoglobuline G</term><term>Mérozoïtes</term><term>Paludisme</term><term>Parasitémie</term><term>Production d'anticorps</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antibody Formation</term><term>Malaria</term><term>Merozoites</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Immunity</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Immunité</term><term>Jeune adulte</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antibodies play a key role in acquired human immunity to Plasmodium falciparum (Pf) malaria and target merozoites to reduce or prevent blood-stage replication and the development of disease. Merozoites present a complex array of antigens to the immune system, and currently, there is only a partial understanding of the targets of protective antibodies and how responses to different antigens are acquired and boosted. We hypothesized that there would be differences in the rate of acquisition of antibodies to different antigens and how well they are boosted by infection, which impacts the acquisition of immunity. We examined responses to a range of merozoite antigens in 2 different cohorts of children and adults with different age structures and levels of malaria exposure. Overall, antibodies were associated with age, exposure, and active infection, and the repertoire of responses increased with age and active infection. However, rates of antibody acquisition varied between antigens and different regions within an antigen following exposure to malaria, supporting our hypothesis. Antigen-specific responses could be broadly classified into early response types in which antibodies were acquired early in childhood exposure and late response types that appear to require substantially more exposure for the development of substantial levels. We identified antigen-specific responses that were effectively boosted after recent infection, whereas other responses were not. These findings advance our understanding of the acquisition of human immunity to malaria and are relevant to the development of malaria vaccines targeting merozoite antigens and the selection of antigens for use in malaria surveillance.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Kenya</li><li>Suède</li><li>États-Unis</li></country><region><li>Maryland</li><li>Svealand</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li><li>Stockholm</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Mccallum, Fiona J" sort="Mccallum, Fiona J" uniqKey="Mccallum F" first="Fiona J" last="Mccallum">Fiona J. Mccallum</name></region><name sortKey="Anders, Robin F" sort="Anders, Robin F" uniqKey="Anders R" first="Robin F" last="Anders">Robin F. Anders</name><name sortKey="Beeson, James G" sort="Beeson, James G" uniqKey="Beeson J" first="James G" last="Beeson">James G. Beeson</name><name sortKey="Crabb, Brendan S" sort="Crabb, Brendan S" uniqKey="Crabb B" first="Brendan S" last="Crabb">Brendan S. Crabb</name><name sortKey="Fowkes, Freya J I" sort="Fowkes, Freya J I" uniqKey="Fowkes F" first="Freya J I" last="Fowkes">Freya J I. Fowkes</name><name sortKey="Gilson, Paul R" sort="Gilson, Paul R" uniqKey="Gilson P" first="Paul R" last="Gilson">Paul R. Gilson</name><name sortKey="Hodder, Anthony N" sort="Hodder, Anthony N" uniqKey="Hodder A" first="Anthony N" last="Hodder">Anthony N. Hodder</name><name sortKey="Mugyenyi, Cleopatra K" sort="Mugyenyi, Cleopatra K" uniqKey="Mugyenyi C" first="Cleopatra K" last="Mugyenyi">Cleopatra K. Mugyenyi</name><name sortKey="Reiling, Linda" sort="Reiling, Linda" uniqKey="Reiling L" first="Linda" last="Reiling">Linda Reiling</name><name sortKey="Richards, Jack S" sort="Richards, Jack S" uniqKey="Richards J" first="Jack S" last="Richards">Jack S. Richards</name><name sortKey="Sanders, Paul R" sort="Sanders, Paul R" uniqKey="Sanders P" first="Paul R" last="Sanders">Paul R. Sanders</name><name sortKey="Simpson, Julie A" sort="Simpson, Julie A" uniqKey="Simpson J" first="Julie A" last="Simpson">Julie A. Simpson</name></country><country name="Suède"><region name="Svealand"><name sortKey="Persson, Kristina E M" sort="Persson, Kristina E M" uniqKey="Persson K" first="Kristina E M" last="Persson">Kristina E M. Persson</name></region></country><country name="Kenya"><noRegion><name sortKey="Williams, Thomas N" sort="Williams, Thomas N" uniqKey="Williams T" first="Thomas N" last="Williams">Thomas N. Williams</name></noRegion><name sortKey="Marsh, Kevin" sort="Marsh, Kevin" uniqKey="Marsh K" first="Kevin" last="Marsh">Kevin Marsh</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Narum, David L" sort="Narum, David L" uniqKey="Narum D" first="David L" last="Narum">David L. Narum</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27837017
|texte= Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27837017" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |